Which is a fine podcast in its own right, I heard about a few interesting applications.
One is JungleDisk, a tool for online backup to S3. It was unexpectedly to hear how the podcasters say, "S3 is definitely not for a consumer". I use it all the time, and the easy-to-use tool is Firefox plugin for S3, but I guess a more polished interface and consumer-oriented focus is better, even if one has to pay 1.5 times. It is not much anyway, either 10 or 15 cents per gigabyte.
Another highly praised one was F-Spot editor for pictures, which is even better than Picasa! Of course, if you are into all things Google, then you will continue using Picasa anyway.